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However, Topamax and Depakote combined create a risk for a condition called hyperammonemic encephalopathy. Symptoms are acute
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DEPAKOTE ER 250 and 500 mg tablets are for oral administration. .. Hyperammonemia with or without lethargy or coma has been reported
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Depacon®; Depakene®; Depakote® Delayed Release; Depakote® ER; Hyperammonemia may occur with therapy and may be present with normal liver
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This leads to hyperammonemia, among other metabolic derangements, and, ultimately, end-organ effects (hepatitis, pancreatitis, hemodynamic
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