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Topical retinoids are derived from vitamin A and formulated for use on the skin. Veltin (tretinoin + clindamycin), and Ziana (tretinoin + clindamycin). The long- term use of topical retinoids for acne may also decrease the risk
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Second, tretinoin sometimes causes significant side effects, such as skin dryness if tazarotene may be a better wrinkle fighter than tretinoin over the long term.
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